Immunoproteasome IFN
Gene co-expression module in CD19⁺ B cells
| Category | Anti-viral |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include immunoproteasome subunits PSMB9, PSME1, PSME2 (interferon-inducible antigen processing), BATF (AP-1 family transcription factor important in B/T cell differentiation), VAMP5, and metallothioneins MT2A, MT1X. The PSMB9/PSME1/PSME2 + IFN-driven theme plus strong inflammation-induced delta (UC 1.28, CD 1.23, sig.) indicates an interferon/immunoproteasome response program. Strong coherence.
Genes
APRT, BATF, MT1X, MT2A, NIT2, PSMB9, PSME1, PSME2, VAMP5
Most correlated modules
- Oxidative Phosphorylation · correlation 0.83
- Actin Cytoskeleton · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.