SCUBA

PSME1 — Proteasome activator subunit 1

PSME1 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PSME1's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmunoproteasome IFN
Anti-viral		APRT, BATF, MT1X, MT2A, NIT2, PSMB9, PSME2, VAMP5View in SCUBA
CD4⁺ T cellsActin Cytoskeleton
Cytoskeletal		ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, MYL12B +6 moreView in SCUBA
CD8⁺ T cellsStress-ISG Response
Stress		CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PLEKHF1, SHISA5 +5 moreView in SCUBA
EndothelialIFN-gamma Antigen Processing
Inflammation		ERAP2, GBP3, IFI35, OAS1, PSMB8, PSMB9, RNF213, SAMD9L +3 moreView in SCUBA
FibroblastsImmunoproteasome MHC-I
Inflammatory		B2M, BST2, EPSTI1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27 +7 moreView in SCUBA
Gamma-delta T cellsOxidative Phosphorylation
Mitochondrial & OxPhos		ARPC1B, ARPC4, ATP6V1F, COPE, COX6A1, COX6B1, COX6C, CSNK2B +12 more
Glial cellsType I/II Interferon Response
Inflammation		GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9 +6 moreView in SCUBA
Innate lymphoid cellsGlycolysis & OxPhos
Metabolism		ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1 +10 moreView in SCUBA
Lymphatic endothelialMHC-I Antigen Presentation
Immune regulation		ATP6V1F, HLA-A, HLA-B, HLA-C, HLA-E, OAZ1, PPP1R14B, PSMB8 +2 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos		ATP5IF1, ATP5MC2, ECH1, FAM89B, GMFG, GSTP1, HIGD2A, LAMTOR4 +9 moreView in SCUBA
MonocytesImmunoproteasome Antigen Processing
Innate immunity		APOL1, APOL4, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9 +5 moreView in SCUBA
Mucosal-associated invariant T cellAntigen Processing
Protein processing & ER		AQP3, ATP5MJ, CAPNS1, CCDC107, CTDNEP1, NCR3, NSA2, PHB2 +8 more
Natural Killer cellsImmunoproteasome Activation
Inflammation		EIF5A, LDHB, PDIA6, PPIA, PSMB3, PSMB8, PSMB9, PSME2View in SCUBA
Smooth muscle cellsProteasome And Translation
Protein processing & ER		ANXA5, EIF2S2, EIF4A1, ENO1, MORF4L1, PSMA4, PSMB3, RBM3 +2 moreView in SCUBA

About the gene

SynonymsIFI5111, PA28alpha
Chromosome14: 24136163-24138967
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.