BATF — Basic leucine zipper ATF-like transcription factor
BATF belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BATF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Immunoproteasome IFN Anti-viral | APRT, MT1X, MT2A, NIT2, PSMB9, PSME1, PSME2, VAMP5 | View in SCUBA |
| CD4⁺ T cells | Activated Treg Immune regulation | ATP5MC1, CTLA4, DNPH1, GBP2, IL2RA, NAMPT, NDFIP2, NINJ2 +6 more | View in SCUBA |
| CD8⁺ T cells | BATF-driven Activation T cell maturation | ARL6IP5, CD82, IL2RG, LAMTOR5, SCAMP2, SH2D2A, SQSTM1, SYNGR2 +2 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, ARHGEF3, CD151, CDK4, FES, FURIN, HLA-F, IL22 +16 more | View in SCUBA |
| Mucosal-associated invariant T cell | Innate Stress Activation Stress | BCL2L1, BRD8, DNAJA3, FAM13A, IL6ST, LRRN3, OXNAD1, PTGER2 +5 more |
About the gene
| Synonyms | B-ATF, BATF1, SFA-2 |
|---|---|
| Chromosome | 14: 75522455-75546993 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Differentiation, Transcription, Transcription regulation |
Function
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class- switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'- TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'- TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.