SCUBA

PSME2 — Proteasome activator subunit 2

PSME2 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PSME2's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmunoproteasome IFN
Anti-viral		APRT, BATF, MT1X, MT2A, NIT2, PSMB9, PSME1, VAMP5View in SCUBA
CD4⁺ T cellsActin Cytoskeleton
Cytoskeletal		ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, MYL12B +6 moreView in SCUBA
CD8⁺ T cellsIFN-gamma Stress Response
Inflammation		COX5B, FABP5, MT1E, MT2A, PHPT1, PSMB9, SUB1, VOPP1View in SCUBA
EndothelialMitochondrial Oxidative Stress
Stress		AGTRAP, AP2M1, ECHS1, ECSCR, EDF1, EIF5A, NEDD8, PARK7 +5 moreView in SCUBA
EnterocytesCore energy metabolism
Mitochondrial & OxPhos		ACAA2, CFL1, CYCS, GAPDH, ME2, P4HB, PPA1, SOD1View in SCUBA
FibroblastsImmunoproteasome MHC-I
Inflammatory		B2M, BST2, EPSTI1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27 +7 moreView in SCUBA
Gamma-delta T cellsGlycolysis & Proteasome
Housekeeping		ACAA2, ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1 +11 more
Glial cellsType I/II Interferon Response
Inflammation		GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9 +6 moreView in SCUBA
Innate lymphoid cellsProteasome ER Proteostasis
Protein processing & ER		ATP5MC1, ATP5PF, DBI, GNG5, GTF3C6, HNRNPK, IL4I1, MANF +19 moreView in SCUBA
Lymphatic endothelialProteasome Assembly
Protein processing & ER		ARPC2, CSTB, DEGS1, GSTO1, MRPL14, PDCD5, POMP, PRELID1 +5 moreView in SCUBA
MacrophagesImmunoproteasome Induction
Inflammatory		CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 moreView in SCUBA
MonocytesImmunoproteasome Antigen Processing
Innate immunity		APOL1, APOL4, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9 +5 moreView in SCUBA
Mucosal-associated invariant T cellType I Interferon
Inflammation		ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2 +6 more
Natural Killer cellsImmunoproteasome Activation
Inflammation		EIF5A, LDHB, PDIA6, PPIA, PSMB3, PSMB8, PSMB9, PSME1View in SCUBA
Smooth muscle cellsType I Interferon
Inflammation		BST2, GBP4, HLA-F, IFI6, IFIT2, IFITM1, ISG15, LY6E +3 moreView in SCUBA

About the gene

SynonymsPA28beta
Chromosome14: 24143362-24147570
Predicted locationIntracellular
Essential geneNo
Protein classPredicted intracellular proteins

Function

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.