Cytotoxic effector
Gene co-expression module in CD4⁺ T cells
| Category | Cytotoxicity |
|---|---|
| Genes | 19 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 19 genes have a known function matching the annotation |
Why this annotation
Strong cytotoxic effector signature: PRF1, GNLY, GZMB, NKG7, FASLG (cytolytic machinery), CCL3/CCL4/CCL4L2 chemokines, IFNG, CSF2, HAVCR2 (TIM-3), ADGRG1 (GPR56). This is a cytotoxic CD4 T cell program, strongly upregulated in inflamed UC and CD tissue. The chemokine and effector cytokine content marks activated cytotoxic effector cells. Module is inflammation-associated and disease-relevant.
Genes
ADGRG1, ATP8B4, CCL3, CCL4, CCL4L2, CSF2, FASLG, GNLY, GZMB, HAVCR2, IFNG, MTX3, NKG7, PRF1, SLC27A2, SMOX, TP63, TXK, ZBED2
Most correlated modules
- Th17 effector · correlation 0.66
- Cytotoxic effector · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.