Cytotoxic effector
Gene co-expression module in CD4⁺ T cells
| Category | Cytotoxicity |
|---|---|
| Genes | 24 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 24 genes have a known function matching the annotation |
Why this annotation
Module dominated by cytotoxicity and NK-like markers: GZMA (granzyme A), KLRD1 (CD94), NCR3 (NKp30), CD244 (2B4), CRTAM, KRT86, LYN. These are classic cytotoxic/NK-associated genes. Strong positive association with CD inflammation. Represents a cytotoxic CD4 T cell (or NK-like) effector program.
Genes
ADAP1, ALOX5AP, AOAH, CD244, CMIP, CPNE7, CRTAM, DAPK2, DOCK5, DPF3, FSD1, GOLIM4, GPR82, GZMA, HIPK2, KLRD1, KRT86, LYN, NCR3, NTRK2, PRR5L, SRGAP3, STARD4, TMIGD2
Most correlated modules
- Th17 lineage · correlation 0.84
- Th17 effector · correlation 0.79
- Inflammatory activation · correlation 0.75
- Gamma-delta T cell · correlation 0.66
- T cell co-receptors · correlation 0.65
- Cytotoxic effector · correlation 0.60
- Integrin adhesion · correlation 0.57
- Immune regulation · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.