Cytotoxic Effector
Gene co-expression module in CD8⁺ T cells
| Category | cytotoxicity |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: B2M and HLA-A/HLA-C are MHC class I components critical for antigen presentation. NKG7 is a core cytotoxic granule protein. CCL5 and CCL4 are effector chemokines secreted by cytotoxic CD8 T cells. GZMH is a granzyme. HCST (DAP10) activates cytotoxic signaling. IL32 is a pro-inflammatory cytokine. CYBA (NOX component) and TMSB4X (thymosin β4, actin sequestering) support effector function. CD52 is expressed on mature lymphocytes. APOBEC3H reflects antiviral/cytidine deaminase activity. Strong coherence (core), high expression (4.05), high detection (82.7%) mark this as a core constitutive effector CD8 program. This is the most broadly expressed module in the batch.
Genes
APOBEC3H, B2M, CCL4, CCL5, CD52, CYBA, GZMH, HCST, HLA-A, HLA-C, IL32, NKG7, TMSB4X
Most correlated modules
- Gut Tissue Residency · correlation 0.77
- Terminal Exhaustion · correlation 0.73
- TCR Complex Signaling · correlation 0.55
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.