TCR Complex Signaling
Gene co-expression module in CD8⁺ T cells
| Category | TCR Signaling |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
CD3E is the canonical CD3 epsilon chain of the TCR complex, making this unmistakably a T cell module. LCK is the src-family kinase essential for TCR proximal signaling. TRBC2 is the T cell receptor beta constant region. TBC1D10C is a GAP protein involved in TCR signaling and T cell quiescence. ACAP1 is an ARF GAP involved in vesicle trafficking and immune cell migration. CITED2 is a transcriptional co-activator modulating HIF and other programs. DUSP1 is a dual specificity phosphatase that dampens MAPK signaling, consistent with a resting or recently activated but dampened state. PNRC1 is involved in mRNA decay. EVL (Ena/VASP-like) regulates actin dynamics in T cells. LAPTM5 is a lysosomal protein expressed in lymphocytes. CD37 is a tetraspanin expressed on lymphocytes. ANXA1 modulates TCR signaling and inflammation resolution. PIK3IP1 inhibits PI3K and restrains T cell activation. Together, the module represents TCR complex expression with signaling modulators, consistent with a resting/homeostatic T cell state with active TCR signaling dampening.
Genes
ACAP1, ANXA1, CD37, CD3E, CITED2, DUSP1, EVL, LAPTM5, LCK, PIK3IP1, PNRC1, TBC1D10C, TRBC2
Most correlated modules
- Heat Shock Response · correlation 0.57
- Cytotoxic Effector · correlation 0.55
- Effector-Memory CD8 · correlation 0.42
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.