Stress-ISG Response
Gene co-expression module in CD8⁺ T cells
| Category | Stress |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include DDIT4 (stress-induced mTOR inhibitor), LY6E and UBE2L6 (interferon-stimulated genes), PSME1 (proteasome PA28α subunit involved in antigen processing downstream of IFN), SOCS1 (cytokine signaling suppressor), and SHISA5 (pro-apoptotic). The module combines cellular stress response with ISG components, centered on DDIT4-mediated mTOR inhibition under stress. VPS28/VPS26A add an endosomal trafficking component (ESCRT/retromer). Moderate coherence reflects this mixed stress-ISG program. Neighbor M44 features exhaustion markers, suggesting these modules co-occur in chronically stimulated/stressed T cells.
Genes
CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PLEKHF1, PSME1, SHISA5, SOCS1, UBE2L6, VPS26A, VPS28, ZYX
Most correlated modules
- Gut Tissue Residency · correlation 0.87
- Actin Cytoskeleton Dynamics · correlation 0.86
- Actin Cytoskeleton · correlation 0.84
- Type I Interferon · correlation 0.83
- Terminal Exhaustion · correlation 0.82
- MHC Class II Presentation · correlation 0.82
- Tumor mediated exhaustion · correlation 0.82
- BATF-driven Activation · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.