SCUBA

ZYX — Zyxin

ZYX belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ZYX's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsStress-ISG Response
Stress
CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PLEKHF1, PSME1 +5 moreView in SCUBA
EndothelialInflammatory Stress Response
Inflammation
ADI1, APLN, ARL6IP1, ARL6IP4, CCDC88A, DAP, GPR68, HEBP2 +11 moreView in SCUBA
FibroblastsFocal Adhesion ECM
Migration & adhesion
ACTN1, CLIC4, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4 +6 moreView in SCUBA
Gamma-delta T cellsTCR Vesicular Trafficking
TCR Signaling
ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3D, CD3G, CD99 +14 more
Innate lymphoid cellsInterferon-Stimulated Genes
Inflammation
ALDOA, CRTAP, DAZAP2, DDX39B, EIF4B, GDI1, GNB2, GRINA +17 moreView in SCUBA
MacrophagesActin Cytoskeleton Organization
Cytoskeletal
ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, DERL1, EIF4G2, GARS1 +20 moreView in SCUBA
Mucosal-associated invariant T cellMitochondrial Housekeeping
Mitochondrial & OxPhos
ARPC3, DUT, GNB2, GPSM3, LSM2, NAA38, NDUFB10, PLEKHJ1 +7 more
Natural Killer cellsNK Activation Signaling
activation
CEP78, PLSCR3, PSAP, RASA3, SLC44A2, SUN2, ZAP70View in SCUBA
Smooth muscle cellsLysosomal-secretory processing
Protein processing & ER
BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RGS9 +5 moreView in SCUBA

About the gene

Chromosome7: 143381295-143391111
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins
Biological processCell adhesion, Host-virus interaction

Function

Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.