PLEKHF1 — Pleckstrin homology and FYVE domain containing 1
PLEKHF1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLEKHF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory activation Immune regulation | ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MAEA +7 more | View in SCUBA |
| CD8⁺ T cells | Stress-ISG Response Stress | CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PSME1, SHISA5 +5 more | View in SCUBA |
| Gamma-delta T cells | Lysosomal Biogenesis Protein processing & ER | ABI3, APLP2, ATP10A, B3GALT4, BAX, CD63, CTNNA1, DOCK5 +14 more | |
| Mucosal-associated invariant T cell | ER Stress Response Protein processing & ER | ACADVL, APOL3, GYG1, HLA-F, HSP90B1, LENG8, MAP4K1, PIM1 +4 more |
About the gene
| Synonyms | APPD, MGC4090, PHAFIN1, ZFYVE15 |
|---|---|
| Chromosome | 19: 29665459-29675477 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Biological process | Apoptosis |
Function
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.