SCUBA

UBE2L6 — Ubiquitin conjugating enzyme E2 L6

UBE2L6 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

UBE2L6's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInterferon response
Anti-viral
ACTN4, CAPZA1, CHMP4A, CHMP5, EFHD2, IL12RB1, LSP1, PARP14 +7 moreView in SCUBA
CD8⁺ T cellsStress-ISG Response
Stress
CD53, DDIT4, DRAP1, DYNLRB1, LY6E, PAIP2, PLEKHF1, PSME1 +5 moreView in SCUBA
EndothelialIFN-gamma Antigen Processing
Inflammation
ERAP2, GBP3, IFI35, OAS1, PSMB8, PSMB9, PSME1, RNF213 +3 moreView in SCUBA
FibroblastsImmunoproteasome MHC-I
Inflammatory
B2M, BST2, EPSTI1, HLA-A, HLA-B, HLA-C, HLA-F, IFI27 +7 moreView in SCUBA
Gamma-delta T cellsGlycolysis & Proteasome
Housekeeping
ACAA2, ANAPC15, APEH, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1 +11 more
Glial cellsType I/II Interferon Response
Inflammation
GBP2, HLA-F, IFI6, IFIT3, ISG15, LY6E, PSMB8, PSMB9 +6 moreView in SCUBA
Innate lymphoid cellsUbiquitin Stress Response
Stress
AIP, AK2, AP2A1, ARMC10, GPAA1, IAH1, NSFL1C, PHF5A +2 moreView in SCUBA
Lymphatic endothelialGIMAP mediated permeability
Mitochondrial & OxPhos
AGTRAP, CCNI, GIMAP1, GIMAP4, GIMAP7, GPR146, HEBP1, LYL1 +2 moreView in SCUBA
MacrophagesImmunoproteasome Induction
Inflammatory
CBR1, DAPP1, DYNLT1, EPSTI1, IFI35, LAP3, LGALS9, LYSMD2 +12 moreView in SCUBA
MonocytesImmunoproteasome Antigen Processing
Innate immunity
APOL1, APOL4, FBXO6, IFI27, IFI35, LGALS3BP, PSMB8, PSMB9 +5 moreView in SCUBA
Mucosal-associated invariant T cellType I Interferon
Inflammation
ABCF2, ACAA2, ANXA2R, BST2, CHST12, IRF9, LY6E, LYSMD2 +6 more

About the gene

SynonymsUBCH8
Chromosome11: 57551656-57568284
Predicted locationIntracellular
Essential geneNo
Protein classEnzymes, Metabolic proteins, Predicted intracellular proteins
Molecular functionTransferase
Biological processUbl conjugation pathway

Function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.