BATF-driven Activation
Gene co-expression module in CD8⁺ T cells
| Category | T cell maturation |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include CD82 (tetraspanin involved in T cell co-stimulation and motility), IL2RG (common gamma chain, essential for cytokine signaling in T cells), BATF (key transcription factor for T cell differentiation, exhaustion and effector programs), TNFRSF18 (GITR, activation/Treg marker but also expressed on activated effector T cells), SH2D2A (TSAd, regulates TCR signaling and T cell migration), SQSTM1 (p62, autophagy/NF-κB), TANK (TRAF-associated, NF-κB signaling). SYNGR2 and SCAMP2 are vesicle/membrane trafficking proteins. LAMTOR5 links to mTOR/lysosomal signaling. The module is coherent around T cell activation signaling (cytokine receptor, TCR proximal, BATF-driven transcription) with an overlay of vesicle trafficking. BATF and TNFRSF18 co-occur in activated/exhausted CD8 T cells in tumors. This module likely reflects a post-activation / early exhaustion transcriptional state driven by BATF.
Genes
ARL6IP5, BATF, CD82, IL2RG, LAMTOR5, SCAMP2, SH2D2A, SQSTM1, SYNGR2, TANK, TNFRSF18
Most correlated modules
- Cytotoxic Exhausted CD8 · correlation 0.91
- Autophagy Metabolic Stress · correlation 0.90
- Tumor mediated exhaustion · correlation 0.89
- TCR Proximal Signaling · correlation 0.86
- T Cell Activation · correlation 0.86
- Gut Residence Trm · correlation 0.84
- Terminal Exhaustion · correlation 0.83
- MHC Class II Presentation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.