Actin Cytoskeleton Dynamics
Gene co-expression module in CD8⁺ T cells
| Category | Cytoskeletal |
|---|---|
| Genes | 8 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes: ACTG1 (actin gamma 1), ARPC2 (Arp2/3 complex, actin branching), ACTR3 (Arp3, actin nucleation), CAP1 (cyclase-associated actin dynamics protein), RAC2 (Rho GTPase regulating actin polymerization and T cell migration/activation), ANXA11 (annexin, membrane/cytoskeletal), CDK2AP2, RNF181. The dominant program is actin cytoskeleton dynamics and cell motility — consistent with T cell migration, immune synapse formation, or cytoskeletal remodeling. RAC2 in T cells is specifically linked to TCR signaling and migration. Neighbor context (M81 with HCLS1 and MAP2K2) further supports cytoskeletal/signaling programs in T cells.
Genes
ACTG1, ACTR3, ANXA11, ARPC2, CAP1, CDK2AP2, RAC2, RNF181
Most correlated modules
- ER-Golgi Trafficking · correlation 0.95
- Vesicle Trafficking · correlation 0.94
- Rho GTPase Cytoskeletal · correlation 0.92
- Actin Cytoskeleton · correlation 0.92
- Metabolic Housekeeping · correlation 0.91
- TCR Proximal Signaling · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
- ER Protein Quality Control · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.