Heat Shock Response
Gene co-expression module in CD8⁺ T cells
| Category | Stress |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by canonical heat shock proteins and chaperones: HSPA8 (HSC70), HSP90AA1, HSP90AB1, DNAJA1 (HSP40 co-chaperone), HSPH1 (HSP110), HSPD1 (HSP60), HSPE1 (HSP10), AHSA1 (HSP90 co-chaperone), and BAG3 (HSP70 co-chaperone). CACYBP is a ubiquitin-related calcyclin-binding protein involved in protein degradation, UBC is ubiquitin C, and CCT3 is a chaperonin subunit. MRPL18 is a mitochondrial ribosomal protein. The module is uniformly expressed with strong coherence, consistent with a proteostasis/stress chaperone response rather than dissociation artifact specifically, though elevated HSP expression can also reflect cellular stress from dissociation. Given the tight clustering around the HSP90/HSP70 axis with co-chaperones, this most precisely represents a heat shock / proteotoxic stress response program.
Genes
AHSA1, BAG3, CACYBP, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8, HSPD1, HSPE1, HSPH1, MRPL18, UBC
Most correlated modules
- Heat Shock Response · correlation 0.85
- Immediate Early Response · correlation 0.84
- Autophagy Metabolic Stress · correlation 0.84
- T Cell Activation · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.