HSPH1 — Heat shock protein family H (Hsp110) member 1

HSPH1 belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HSPH1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	BAG3, CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6 +13 more	View in SCUBA
CD4⁺ T cells	Heat Shock Response Stress	ANKRD37, CHORDC1, DEDD2, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1 +12 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8 +4 more	View in SCUBA
Endothelial	Heat Shock Response Stress	BAG3, DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, IER5, MRPL18 +2 more	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, IER5, MIDN +5 more	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4 +13 more
Glial cells	Integrated Stress Response Stress	ATF3, CCNL1, DNAJA1, DUSP1, HSPA8, KLF4, MAFF, NR4A1 +2 more	View in SCUBA
Goblet cells	Heat Shock Response Stress	DNAJA1, EIF1AX, EIF5, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +5 more	View in SCUBA
Innate lymphoid cells	Heat Shock Response Stress	AHSA1, ANKRD37, DEDD2, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A +9 more	View in SCUBA
Lymphatic endothelial	Heat Shock Response Stress	BAG3, DNAJB1, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1 +3 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	Heat Shock Response Stress	CHORDC1, DNAJA1, DNAJB1, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B, HSPA8 +4 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, BAG3, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4 +13 more
Natural Killer cells	Heat Shock Response Stress	AHSA1, ANKRD37, CACYBP, CHORDC1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +3 more	View in SCUBA
Pericytes	Proteotoxic Stress Response Stress	BAG3, CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, SLC2A3, TRA2B +1 more	View in SCUBA
Smooth muscle cells	Heat Shock Response Stress	C12orf65, CEMIP2, CHORDC1, DNAJA1, DNAJB1, FOSB, H2AFX, HSP90AA1 +8 more	View in SCUBA

About the gene

Synonyms	HSP105A, HSP105B, KIAA0201, NY-CO-25
Chromosome	13: 31134973-31162388
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Stress response

Function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.