Autophagy Metabolic Stress
Gene co-expression module in CD8⁺ T cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Top hub EFHD2 (swiprosin-1) is expressed in activated T cells and regulates cytoskeletal dynamics and apoptosis. CTSC (cathepsin C) processes granzymes in cytotoxic lymphocytes. ICOS (inducible co-stimulator) marks activated/follicular helper-like or exhausted T cells. SH3GLB1 (Bif-1) is involved in autophagy and mitochondrial dynamics. MAP1LC3B is a canonical autophagy marker. NDUFC1 is a mitochondrial complex I subunit. DNAJB6 is a chaperone. GNG2 is a G-protein subunit in TCR/chemokine signaling. DOK2 is a negative regulator of T cell activation. CREM is induced by T cell activation and regulates cytokine gene expression. REEP5 is an ER-shaping protein. The module shows moderate coherence and combines autophagy/mitochondrial stress signals with T cell activation (ICOS, CREM, DOK2), suggesting metabolically stressed activated CD8 T cells undergoing autophagy. Given neighbor context of exhaustion modules, this likely reflects a metabolic stress/autophagy overlay in activated or exhausted T cells.
Genes
CREM, CTSC, DNAJB6, DOK2, EFHD2, GNG2, ICOS, MAP1LC3B, NDUFC1, REEP5, SH3GLB1
Most correlated modules
- BATF-driven Activation · correlation 0.90
- ER Protein Quality Control · correlation 0.88
- IFN-gamma Response · correlation 0.87
- TCR Proximal Signaling · correlation 0.87
- Cytotoxic Exhausted CD8 · correlation 0.85
- RNA Processing Mixed · correlation 0.85
- Heat Shock Response · correlation 0.84
- Tumor mediated exhaustion · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.