BAG3 — BAG cochaperone 3

BAG3 belongs to a gene co-expression module in 14 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

BAG3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Heat Shock Response Stress	CHORDC1, DDIT4, DEDD2, DNAJA4, DNAJB1, DNAJB4, DNAJB6, EIF5 +13 more	View in SCUBA
CD4⁺ T cells	Heat-shock response Stress	AHSA1, CACYBP, CCDC117, DNAJB6, DYNLL1, FKBP4, GADD45G, HSPA6 +5 more	View in SCUBA
CD8⁺ T cells	Heat Shock Response Stress	AHSA1, CACYBP, CCT3, DNAJA1, HSP90AA1, HSP90AB1, HSPA8, HSPD1 +4 more	View in SCUBA
Endothelial	Heat Shock Response Stress	DNAJA1, DNAJA4, HSPA8, HSPD1, HSPE1, HSPH1, IER5, MRPL18 +2 more	View in SCUBA
Fibroblasts	Proteotoxic Stress Survival Stress	ARL5B, DNAJA4, ICAM1, PPIF, PPP1R15B, SLC25A25, TIPARP, TNFRSF10D	View in SCUBA
Gamma-delta T cells	Heat Shock Response Stress	AHSA1, CACYBP, CCT4, CHORDC1, DNAJA1, DNAJB1, DNAJB4, HSP90AA1 +13 more
Glial cells	Integrated Stress Response Stress	ANKRD37, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MCL1, MIDN +3 more	View in SCUBA
Lymphatic endothelial	Heat Shock Response Stress	DNAJB1, DNAJB4, HSP90AA1, HSPA1A, HSPA1B, HSPA6, HSPB1, HSPE1 +3 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4, DUSP1 +39 more	View in SCUBA
Monocytes	Co-chaperone Proteostasis Stress	AHSA1, ALAS1, CACYBP, FBXL14, FKBP4, HSPA6, HSPB1, SERPINH1 +2 more	View in SCUBA
Mucosal-associated invariant T cell	Heat Shock Response Stress	AHSA1, CACYBP, CAPG, CHORDC1, CSF1, DNAJA4, DNAJB4, GPR174 +13 more
Natural Killer cells	Inducible HSP70 Stress Stress	DNAJB1, FKBP4, HSPA1A, HSPA1B, HSPA4, HSPA6, HSPB1, RHOB +2 more	View in SCUBA
Pericytes	Proteotoxic Stress Response Stress	CDKN1A, DDX3X, DNAJA4, DUSP5, HES1, HSPH1, SLC2A3, TRA2B +1 more	View in SCUBA
Smooth muscle cells	BAG3-HSPB8 proteostasis Stress	C6orf62, CREBRF, DNAJB4, EOGT, GOLGB1, HSPB8, IFRD1, PPP2R5E +5 more	View in SCUBA

About the gene

Chromosome	10: 119651380-119677819
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Molecular function	Chaperone
Biological process	Apoptosis

Function

Co-chaperone and adapter protein that connects different classes of molecular chaperones including heat shock proteins 70 (HSP70s), e.g. HSPA1A/HSP70 or HSPA8/HSC70, and small heat shock proteins (sHSPs), e.g. HSPB8. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from HSP70s, thereby triggering client protein release. Nucleotide release is mediated via BAG3 binding to the nucleotide-binding domain (NBD) of HSP70s, whereas client release is mediated via binding to the substrate-binding domain (SBD). Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.