MCM Helicase Loading
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 14 genes have a known function matching the annotation |
Why this annotation
MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 (the entire MCM2-7 replicative helicase complex), GINS2 (GINS complex, part of CMG helicase), CDC45 (CMG helicase component), RFC2 (replication factor C), E2F1 (master transcription factor for S-phase gene expression), HELLS (SNF2-family helicase, replication-coupled chromatin remodeling), CDCA7 (E2F target, DNA methylation maintenance), UNG (uracil-DNA glycosylase, base excision repair during replication), DCTPP1 (nucleotide sanitization). This is the canonical MCM helicase/CMG complex loading and S-phase transcription module, driven by E2F1. Neighbor context: the most upstream module of the cell cycle cluster — MCM loading precedes the replication fork machinery of M82 and checkpoint of M64.
Genes
CDC45, CDCA7, DCTPP1, E2F1, GINS2, HELLS, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, RFC2, UNG
Most correlated modules
- DNA Replication Fork · correlation 0.94
- Histone Synthesis S-phase · correlation 0.92
- Replication Stress Checkpoint · correlation 0.89
- S-phase Progression · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.