DNA Replication Fork
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 14 genes have a known function matching the annotation |
Why this annotation
PCNA (processivity clamp, central DNA replication hub), RFC4 (replication factor C), FEN1 (flap endonuclease, Okazaki fragment maturation), LIG1 (DNA ligase I, joins Okazaki fragments), DHFR (dihydrofolate reductase, thymidylate biosynthesis), TK1 (thymidine kinase 1, dTTP synthesis), DUT (dUTPase, nucleotide pool), CDT1 (replication licensing), CDC6 (pre-RC, replication initiation), UHRF1 (epigenetic maintenance during replication), CHAF1A (chromatin assembly factor 1, histone deposition), WDR76 (PCNA-interacting), PSMC3IP (DNA strand exchange). This is a textbook DNA replication fork module — tightly coherent and centered on lagging-strand synthesis and nucleotide metabolism. Neighbor context: highly complementary to M78 (MCM helicase loading) and M64 (checkpoint/repair).
Genes
CDC6, CDT1, CHAF1A, CTNNAL1, DHFR, DUT, FEN1, LIG1, PCNA, PSMC3IP, RFC4, TK1, UHRF1, WDR76
Most correlated modules
- S-phase Progression · correlation 0.96
- Replication Stress Checkpoint · correlation 0.96
- Histone Synthesis S-phase · correlation 0.95
- MCM Helicase Loading · correlation 0.94
- Cellular Housekeeping · correlation 0.92
- Replication Licensing · correlation 0.92
- G2/M Checkpoint · correlation 0.86
- Epigenetic Chromatin Maintenance · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.