DCTPP1 — DCTP pyrophosphatase 1

DCTPP1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

DCTPP1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Nucleotide Metabolism Biosynthesis Mitochondrial & OxPhos	ATIC, ATP5MC1, C1QBP, CCT7, EBNA1BP2, EEF1E1, EIF5A, GADD45GIP1 +13 more	View in SCUBA
CD4⁺ T cells	Nucleotide biosynthesis Housekeeping	CCT7, COPRS, MRPL12, MRPL4, NHP2, NME1, PPA1, PRDX4 +6 more	View in SCUBA
CD8⁺ T cells	MCM Helicase Loading Cell cycle	CDC45, CDCA7, E2F1, GINS2, HELLS, MCM2, MCM3, MCM4 +5 more	View in SCUBA
Endothelial	Housekeeping Metabolic Housekeeping	ANXA5, ATP5MC3, CCT5, COX6B1, CTSL, ERH, GSTO1, NDUFB7 +8 more	View in SCUBA
Gamma-delta T cells	Cell Cycle Entry Cell cycle	CDK4, FH, GGCT, GSS, ISOC2, MBD3, MTHFD1, NABP2 +4 more
Hematopoietic progenitor cells	Nucleotide Metabolism Housekeeping	DNPH1, EIF4EBP1, FKBP4, GCSH, METTL26, MRPL12, NHP2, NME4 +2 more
Macrophages	Mitotic Spindle Assembly Cell cycle	ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more	View in SCUBA
Mucosal-associated invariant T cell	Mitochondrial Ribosome Mitochondrial & OxPhos	AGTRAP, BRK1, C11orf68, C14orf119, CNPY2, CZIB, DYNC1I2, FOXN2 +22 more

About the gene

Synonyms	CDA03, MGC5627, RS21C6, XTP3TPA
Chromosome	16: 30423615-30430030
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Hydrolase

Function

Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.