GINS2 — GINS complex subunit 2
GINS2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GINS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | CDC45, CENPH, DHFR, FEN1, MCM3, MCM5, MCM7, PCNA +3 more | View in SCUBA |
| CD8⁺ T cells | MCM Helicase Loading Cell cycle | CDC45, CDCA7, DCTPP1, E2F1, HELLS, MCM2, MCM3, MCM4 +5 more | View in SCUBA |
| Goblet cells | MCM Replication Licensing Cell cycle | CDT1, DNMT1, DUT, FAM111B, HELLS, MCM3, MCM4, MCM5 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, E2F1, FEN1, GMNN, PCLAF +4 more |
About the gene
| Synonyms | Pfs2, PSF2 |
|---|---|
| Chromosome | 16: 85676198-85690073 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | DNA replication |
Function
Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.