MHC-II Antigen Presentation
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
The module is overwhelmingly composed of MHC class II genes (HLA-DRA, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DRB1, HLA-DQA1, HLA-DRB5, HLA-DOA) and CD74 (the MHC-II invariant chain essential for antigen loading). This is a canonical antigen presentation via MHC-II module. High coherence and uniform expression suggest a subset of HPCs or monocyte-primed progenitors expressing MHC-II machinery.
Genes
CD74, GSTP1, HLA-DOA, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5
Most correlated modules
- Myeloid Commitment · correlation 0.70
- MHC-I Antigen Presentation · correlation 0.70
- Quiescent HSC State · correlation 0.70
- Multipotent Progenitor State · correlation 0.62
- Lymphoid Progenitor TFs · correlation 0.62
- Lymphocyte Signaling · correlation 0.61
- Multipotent Progenitor Identity · correlation 0.59
- Megakaryocyte IFN-primed · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.