Lymphocyte Signaling
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 12 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
CYTH4 (cytohesin-4, lymphocyte ARF GEF), AKNA (lymphocyte-specific transcription factor), LSP1 (lymphocyte-specific protein 1), CORO1A (coronin-1A, essential for lymphocyte actin dynamics and egress), CARD11 (lymphocyte NF-κB scaffold), PIK3AP1 (B-cell PI3K adapter BCAP), PAK1 (Rac/Cdc42 effector in lymphocytes), AHR (regulates lymphocyte differentiation), RAB11FIP1/4 (endosomal recycling in immune cells), ADGRG5 (lymphocyte GPCR). Core coherence. Topological neighbor to M30, reinforcing a lymphocyte program with a slight B-cell/actin-signaling skew.
Genes
ADGRG5, AHR, AKNA, CARD11, CORO1A, CYTH4, KIAA0930, LSP1, PAK1, PIK3AP1, RAB11FIP1, RAB11FIP4
Most correlated modules
- T/NK Cell Identity · correlation 0.88
- Regulatory T-cell State · correlation 0.88
- ILC/NK Development · correlation 0.87
- Dendritic Cell Progenitor · correlation 0.85
- MHC-I Antigen Presentation · correlation 0.83
- Lymphoid Progenitor TFs · correlation 0.82
- Naive B Cell · correlation 0.75
- Myeloid Innate Immune · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.