Quiescent HSC State
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
HOPX is a well-validated marker of quiescent long-term HSCs (LT-HSCs), distinguishing the most primitive stem cell pool from actively cycling progenitors. SPINK2 (serine protease inhibitor) is a specific marker of HSCs and early multipotent progenitors in human bone marrow. BAALC is expressed in early hematopoietic progenitors and marks immature myeloid cells. Together, HOPX + SPINK2 + BAALC define an early/quiescent HSC state. CD52 is broadly expressed on lymphocytes and some progenitors. MZB1 (marginal zone B and B1 cell-specific protein) and BIN1 introduce some lymphoid flavor, possibly reflecting lymphoid-biased HSCs or contamination from rare B-lineage cells. GNAI1 mediates HSC niche retention signaling. The module is dominated by the quiescent HSC signature.
Genes
ARHGEF17, BAALC, BIN1, CD52, GNAI1, HOPX, MZB1, RBPMS, SPINK2
Most correlated modules
- Myeloid Commitment · correlation 0.85
- Multipotent Progenitor Identity · correlation 0.84
- Lymphoid-Primed Progenitor · correlation 0.80
- Multipotent Progenitor State · correlation 0.80
- Early Myeloid Progenitor · correlation 0.78
- HOX HSC Program · correlation 0.76
- Megakaryocyte IFN-primed · correlation 0.75
- MHC-II Antigen Presentation · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.