Lymphoid Progenitor TFs

Gene co-expression module in Hematopoietic progenitor cells

Why this annotation

Hub genes include AFF3 (lymphoid transcription factor), TCF4 (E2-2, master regulator of plasmacytoid DC and B cell development), MEF2C (myeloid/lymphoid transcription factor), SP110 (nuclear body protein, immune regulation), HLA-DMB (MHC class II antigen presentation), RNF213 (innate immune/interferon response), CYLD (deubiquitinase regulating NF-kB in lymphocytes), ADAM28 (lymphocyte-expressed metalloprotease), CYFIP2 and ANKRD44 (signaling scaffolds). The combination of TCF4, MEF2C, AFF3, SP110, HLA-DMB, and CYLD points strongly to a lymphoid progenitor or common lymphoid progenitor transcriptional program. PDE7A is expressed in lymphocytes. SH2D3C links to lymphocyte signaling. This module overlaps with M4 and M59 as topological neighbors — all three modules carry lymphoid identity genes (B/T/lymphoid progenitor markers), consistent with a shared lymphoid commitment program. M51 appears to represent the transcription factor/regulatory layer of early lymphoid specification, while M4 and M59 capture more committed B-lineage programs. Concordant genes: AFF3, TCF4, MEF2C, SP110, HLA-DMB, CYLD, RNF213, ADAM28, PDE7A, CYFIP2, SH2D3C.

Genes

ADAM28, AFF3, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A, RNASEH2B, RNF213, SH2D3C, SP110, TCF4

Most correlated modules

• T/NK Cell Identity · correlation 0.93
• Naive B Cell · correlation 0.92
• HOX HSC Program · correlation 0.88
• Multipotent Progenitor Identity · correlation 0.86
• Myeloid Commitment · correlation 0.84
• Lymphocyte Signaling · correlation 0.82
• Regulatory T-cell State · correlation 0.82
• Lymphoid-Primed Progenitor · correlation 0.81

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.