HLA-DOA — Major histocompatibility complex, class II, DO alpha
HLA-DOA belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HLA-DOA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | MHC-II antigen presentation B cell maturation | CD53, CD81, CYTH1, DAPP1, DNAJC10, FAM3C, FCRLA, GPR18 +11 more | View in SCUBA |
| Endothelial | MHC Class II Presentation Inflammation | CD74, CIITA, CST3, GSTK1, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1 +7 more | View in SCUBA |
| Glial cells | MHC-II Antigen Presentation Inflammation | C2, CD74, CIITA, HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DPB1, HLA-DQA1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | MHC-II Antigen Presentation Myeloid development | CD74, GSTP1, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 +1 more | |
| Macrophages | Macrophage Identity Innate immunity | CCDC88B, CSF1R, CYP4V2, CYSLTR1, EVL, FAM53B, FOXRED2, GATM +15 more | View in SCUBA |
About the gene
| Synonyms | HLA-D0-alpha, HLA-DNA, HLA-DZA |
|---|---|
| Chromosome | 6: 33004182-33009591 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Adaptive immunity, Immunity |
Function
Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.