MHC-I Antigen Presentation
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 19 genes have a known function matching the annotation |
Why this annotation
HLA-A, HLA-B, B2M (MHC class I antigen presentation), TYROBP/DAP12 (myeloid/NK signaling adapter), EVI2A, EVI2B (myeloid differentiation markers), CYBA (p22phox, NADPH oxidase subunit, myeloid), FUT7 (sialyl-Lewis X synthesis, myeloid/neutrophil), CAPG (macrophage-enriched actin capping protein), LITAF (LPS-induced TNF factor, myeloid), IRF1 (interferon regulatory factor). ACTB, TMSB4X, PFN1, IQGAP1 are cytoskeletal housekeeping genes adding noise (moderate coherence). The dominant biological signal is MHC-I antigen presentation in a myeloid context, consistent with dendritic cells or monocytes among HPCs.
Genes
ACTB, B2M, CALM2, CAPG, CYBA, EVI2A, EVI2B, FUT7, HLA-A, HLA-B, IQGAP1, IRF1, LITAF, PFN1, PLP2, SNRNP25, TESC, TMSB4X, TYROBP
Most correlated modules
- Lymphocyte Signaling · correlation 0.83
- T/NK Cell Identity · correlation 0.78
- Regulatory T-cell State · correlation 0.74
- MHC-II Antigen Presentation · correlation 0.70
- Dendritic Cell Progenitor · correlation 0.70
- Myeloid Commitment · correlation 0.69
- Lymphoid Progenitor TFs · correlation 0.68
- ILC/NK Development · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.