Multipotent Progenitor State
Gene co-expression module in Hematopoietic progenitor cells
| Category | Stemness |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
FLT3 is a key marker of multipotent and lymphoid-primed progenitors; PROM1 (CD133) marks primitive HSCs/progenitors; CD44 is expressed on HSCs and early progenitors; IL6R modulates progenitor expansion; PRAM1 is a myeloid progenitor-associated gene; PLCB1 mediates cytokine receptor signaling in progenitors. Together these define an early multipotent HPC/progenitor identity, consistent with FLT3+ multipotent progenitors.
Genes
CD44, CD99, FLT3, GBP2, GLIPR1, IL6R, PLCB1, PRAM1, PROM1
Most correlated modules
- Quiescent HSC State · correlation 0.80
- Multipotent Progenitor Identity · correlation 0.73
- Megakaryocyte IFN-primed · correlation 0.73
- Myeloid Commitment · correlation 0.67
- MHC-II Antigen Presentation · correlation 0.62
- Glucocorticoid Response · correlation 0.60
- Interferon Stimulated · correlation 0.59
- Lymphoid Progenitor TFs · correlation 0.56
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.