ILC-1 identity
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub genes include TRBC1 (T-cell receptor beta chain), LTB (lymphotoxin-B, expressed in T/NK cells), CD52 (pan-lymphocyte marker strongly expressed on T cells), KRT86/KRT81 (keratins), and SLA (Src-like adaptor, T-cell signaling). TRBC1 is a definitive T-cell marker, and the strong ILC1 enrichment (3-7x) combined with T-cell receptor components suggests T-cell contamination captured within the ILC1/NK gate. The module coherence is moderate with mostly weak membership scores, consistent with a contamination signal mixing T-cell transcripts into NK/ILC1 cells.
Genes
ABRACL, BLOC1S1, C19orf53, CD52, DAD1, FUCA2, GMFG, HMGN3, ISCU, ITGB1, KRT81, KRT86, LST1, LTB, METTL9, MPG, OSTF1, PEBP1, PGLS, PHPT1, RGS10, SELENOT, SLA, SRI, TMBIM4, TMEM230, TRBC1, VAMP8, VPS28
Most correlated modules
- Actin Cytoskeleton Dynamics · correlation 0.95
- Glycolysis & OxPhos · correlation 0.95
- Actin Cytoskeleton Remodeling · correlation 0.94
- SUMOylation Program · correlation 0.93
- ILC1 Inflammatory Activation · correlation 0.92
- RNA Processing & Proteostasis · correlation 0.91
- ILC1 Inflammatory Activation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.