Mitochondrial Metabolism
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 21 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
The module is dominated by mitochondrial genes: VDAC3 (outer membrane channel), ECHS1 (fatty acid oxidation), MRPS34 and MRPL41 (mitochondrial ribosomes), SLC25A11 (mitochondrial carrier), ETFB (electron transfer flavoprotein), HIGD1A (mitochondrial hypoxia response), and ATP6V1E1 (vacuolar ATPase). Additional genes include RNA processing (LSM6, THOC7), DNA repair (ERCC1), and ER function (TOR1A). The module is enriched in ILC1 cells (~2-3x) and represents a mitochondrial metabolic/housekeeping program characteristic of ILC1s. Moderate coherence with many weak-membership genes reflects the mixed nature of housekeeping functions co-expressed in this ILC1 state.
Genes
ACTR10, ANP32A, APOL3, ATP6V1E1, ECHS1, ERCC1, ETFB, GLRX3, HIGD1A, LSM6, MRPL41, MRPS34, PGM2L1, SCOC, SLC25A11, SSNA1, THOC7, TOR1A, TPMT, UROS, VDAC3
Most correlated modules
- Lipid & Isoprenoid Metabolism · correlation 0.97
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- mTOR Metabolic Stress · correlation 0.95
- Mitochondrial Lysosomal Housekeeping · correlation 0.95
- Mitochondrial OxPhos · correlation 0.94
- RNA Processing & Proteostasis · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- ILC1 Inflammatory Activation · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.