PMVK — Phosphomevalonate kinase

PMVK belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PMVK's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Oxidative Phosphorylation Mitochondrial & OxPhos	ANAPC11, AP2S1, ATP5F1A, ATP5F1C, COPE, COX8A, GAPDH, GNG5 +7 more	View in SCUBA
CD4⁺ T cells	Activated effector Tcell Immune regulation	APOBEC3C, ARPP19, CISD2, CTSC, ENTPD1, GLUD1, IL2RB, LYST +4 more	View in SCUBA
Endothelial	Arterial EC Identity Endothelial cell development	CCDC71L, FABP4, LAPTM5, MAP3K1, MDK, PCBD1, RASSF4, SCNN1B +2 more	View in SCUBA
Innate lymphoid cells	ILC1 Inflammatory Activation Inflammation	ABHD15, ALDOC, ARL2BP, C20orf204, CCL20, CPNE7, EIPR1, ERG28 +21 more	View in SCUBA
Macrophages	Inflammasome Oxidative Stress Inflammatory	ABI3, ADISSP, AKR1A1, ARHGDIB, ARPC1B, ASCL2, BLVRA, C1orf54 +33 more	View in SCUBA

About the gene

Synonyms	HUMPMKI, PMK, PMKA
Chromosome	1: 154924740-154936719
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Molecular function	Kinase, Transferase
Biological process	Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Function

Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.