RGS9 — Regulator of G protein signaling 9
RGS9 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RGS9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Cytotoxic Effector Program cytotoxicity | ADGRG1, ANXA4, CADM1, CX3CR1, FCGR3A, FGFBP2, FGL2, GNLY +14 more | |
| Innate lymphoid cells | ILC1 Inflammatory Activation Inflammation | ABHD15, ALDOC, ARL2BP, C20orf204, CCL20, CPNE7, EIPR1, ERG28 +21 more | View in SCUBA |
| Natural Killer cells | NK Activation Signaling activation | C12orf75, F2R, GRAP2, GZMH, LIME1, LYAR, SSBP3, SYT11 +1 more | View in SCUBA |
| Smooth muscle cells | Lysosomal-secretory processing Protein processing & ER | BZW2, COPZ1, CTSL, LAMP1, PIGT, PLOD2, PRMT2, RPN2 +5 more | View in SCUBA |
About the gene
| Synonyms | MGC111763, MGC26458, PERRS, RGS9L |
|---|---|
| Chromosome | 17: 65100812-65227703 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
| Biological process | Sensory transduction, Vision |
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.