Ubiquitin Stress Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include AP2A1 (clathrin adaptor protein 2, endocytosis), TRADD (TNFR1-associated death domain protein, TNF/apoptosis signaling), GPAA1 (GPI anchor biosynthesis), ARMC10 (mitochondrial dynamics/fission), NSFL1C (p47, AAA-ATPase cofactor for membrane fusion/ER), AIP (aryl hydrocarbon receptor interacting protein), UBE2V2 and UBE2L6 (ubiquitin-conjugating enzymes), PHF5A (splicing), and AK2 (adenylate kinase, nucleotide metabolism). UBE2L6 is notably ISG15-conjugating enzyme and interferon-stimulated. The module is enriched in ILC1s (~2-3x). The mix of ubiquitin pathway (UBE2V2, UBE2L6), endocytosis (AP2A1), death domain signaling (TRADD), and GPI biosynthesis (GPAA1) suggests a stress/proteostasis or TNF-response program. UBE2L6 is a strong ISG15 E2 enzyme involved in antiviral/interferon response. TRADD links to TNF receptor signaling. The module is moderate coherence with all weak memberships except UBE2L6 (strong). This is likely a mixed module combining ubiquitin-proteasome stress and TNF/death receptor signaling, most parsimoniously labeled as ubiquitin-mediated stress response.
Genes
AIP, AK2, AP2A1, ARMC10, GPAA1, IAH1, NSFL1C, PHF5A, TRADD, UBE2L6, UBE2V2
Most correlated modules
- Glycolysis & OxPhos · correlation 0.94
- Mitochondrial Lysosomal Housekeeping · correlation 0.94
- Mitochondrial OxPhos · correlation 0.94
- ILC1 Inflammatory Activation · correlation 0.93
- ILC1 Lymphocyte Signaling · correlation 0.92
- RNA Processing Mixed · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.