Glycolysis & OxPhos
Gene co-expression module in Innate lymphoid cells
| Category | Metabolism |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 19 genes have a known function matching the annotation |
Why this annotation
Strong coherence module with clear metabolic identity. COX6A1, COX6B1, and ATP5MC3 are oxidative phosphorylation subunits; PGAM1 and TALDO1 are glycolytic/pentose phosphate enzymes; PPIB is an ER chaperone/protein folding factor; PSME1 is a proteasome activator; RHOA and RAC2 are Rho GTPases involved in cytoskeletal regulation. CD74 and IL2RG add immune context (ILC1 identity) but the dominant co-expressed program is cellular energy metabolism spanning glycolysis and OxPhos. Strong coherence and consistent ILC1 enrichment support a genuine metabolic state.
Genes
ANXA7, ARF3, ATP5MC3, CD320, CD74, CNBP, COX6A1, COX6B1, IL2RG, IMP4, PGAM1, PPIB, PSME1, RAC2, RHOA, TALDO1, TMED10, TMEM50A, UBE2F
Most correlated modules
- Actin Cytoskeleton Dynamics · correlation 0.95
- ILC1 Inflammatory Activation · correlation 0.95
- Ubiquitin Stress Response · correlation 0.94
- Mixed Proteostasis Metabolism · correlation 0.94
- ILC1 Cytoskeletal Metabolic · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.