Mitochondrial OxPhos
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial oxidative phosphorylation components: NDUFA11 and NDUFB8 (Complex I), SDHC (Complex II), COX5B (Complex IV), ATP5MC2 and ATP5PB (ATP synthase/Complex V). FIS1 encodes a mitochondrial fission protein. LDHB and SELENOH are peripheral metabolic/antioxidant members. The module is moderately coherent with several weak-membership genes (SDHC, ANXA6, LSP1), suggesting a core OxPhos program with peripheral members. All top genes are enriched in ILC1 cells (~2-4x), consistent with metabolically active tissue-resident ILC1s. Neighbor M79 also contains OxPhos genes (ATP5PO, COX4I1), reinforcing that this batch captures mitochondrial metabolic programs in ILC1/NK cells.
Genes
AKR7A2, ANXA6, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG, CCNDBP1, CLNS1A, CNPY2, COX5B, CUTA, EIF3F, EIF3K, FBL, FIS1, GDI2, HMGN2, LDHB, LSP1, NDUFA11, NDUFB8, SDHC, SELENOH, SSR2, TMEM14C, TMEM256, TMEM258, WDR83OS
Most correlated modules
- Glycolysis & OxPhos · correlation 0.96
- Proteasome & COPI Trafficking · correlation 0.96
- Actin Cytoskeleton Dynamics · correlation 0.95
- Mitochondrial Metabolic Housekeeping · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
- Mitochondrial Lysosomal Housekeeping · correlation 0.94
- ILC1 Cytoskeletal Metabolic · correlation 0.94
- Ubiquitin Stress Response · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.