Mitochondrial Lysosomal Housekeeping
Gene co-expression module in Innate lymphoid cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 16 genes have a known function matching the annotation |
Why this annotation
PSMC3 is a 26S proteasome ATPase subunit (19S regulatory particle). PRDX3 is a mitochondrial peroxiredoxin (antioxidant). NDUFB10 and NDUFAF3 are complex I subunits/assembly factors. ETFA is electron transfer flavoprotein alpha (mitochondrial fatty acid oxidation). MRPL14 and MRPS16 are mitochondrial ribosomal proteins. RAB5C is an endosomal Rab GTPase. LAMP1 is a lysosomal membrane protein. IER3IP1 is an ER membrane protein. EMC6 is an ER membrane complex subunit. JTB is a Golgi-associated protein. NAXE is an NAD(P)HX epimerase (metabolic repair). NUDCD2 is a co-chaperone. BTF3L4 is a transcription factor. C14orf119 is poorly characterized. The module has many weak membership scores, indicating loose co-regulation. The dominant themes are mitochondrial function (PRDX3, NDUFB10, NDUFAF3, ETFA, MRPL14, MRPS16) and lysosomal/ER components (LAMP1, RAB5C, IER3IP1, EMC6). The treatment response signal (delta_treatment_post_pre = 0.155) is notable. This is a mixed mitochondrial/lysosomal housekeeping module in ILC1s.
Genes
BTF3L4, C14orf119, EMC6, ETFA, IER3IP1, JTB, LAMP1, MRPL14, MRPS16, NAXE, NDUFAF3, NDUFB10, NUDCD2, PRDX3, PSMC3, RAB5C
Most correlated modules
- Mixed Proteostasis Metabolism · correlation 0.96
- Glycolysis & OxPhos · correlation 0.96
- Proteasome & COPI Trafficking · correlation 0.96
- Mitochondrial OxPhos · correlation 0.95
- Actin Cytoskeleton Dynamics · correlation 0.95
- Mitochondrial OxPhos Biogenesis · correlation 0.95
- Mitochondrial Metabolism · correlation 0.95
- mTOR Metabolic Stress · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.