ILC1 Lymphocyte Signaling
Gene co-expression module in Innate lymphoid cells
| Category | Immune regulation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
This weak-coherence module is dominated by genes with strong ILC1 enrichment (2.2–4.3x). Hub genes include LIMD2 (LIM domain protein involved in immune cell migration/signaling), PTPN6 (SHP-1, a key phosphatase in NK/ILC signaling), IL16 (lymphocyte chemoattractant cytokine), SASH3 (scaffold in lymphocyte signaling), SNX20 (sorting nexin in immune receptor trafficking), PRAM1 (hematopoietic signaling scaffold), WAS (Wiskott-Aldrich syndrome protein, actin/immune signaling), TRAF3IP3 (TRAF3-interacting protein in lymphocyte signaling), and MAPKAPK3 (stress-activated kinase). The consistent ILC1 enrichment and signaling gene composition suggest this module reflects ILC1-enriched lymphocyte signaling programs. The weak coherence and all-weak membership indicate a loosely co-regulated set. ENG (endoglin) is an outlier but has moderate membership. The module is not clearly a contamination module since ILC1 is a closely related NK/ILC lineage subset. The overall signature points to general lymphocyte/ILC1 signaling rather than a specific pathway.
Genes
CDIPT, CNPY3, DBNL, ENG, IL16, LIMD2, LSM2, MAPKAPK3, PHYKPL, PLD3, PRAM1, PTPN6, RAB6A, RPA1, SASH3, SMARCB1, SNX20, TPGS2, TRAF3IP3, WAS
Most correlated modules
- JAK-STAT Cytokine Signaling · correlation 0.93
- ILC1 Actin Motility · correlation 0.93
- Mitochondrial Metabolic Housekeeping · correlation 0.93
- ILC Transcription Factor Program · correlation 0.92
- Ubiquitin Stress Response · correlation 0.92
- Actin Cytoskeletal Regulation · correlation 0.90
- RNA Processing Mixed · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.