JAK-STAT Cytokine Signaling
Gene co-expression module in Innate lymphoid cells
| Category | Inflammation |
|---|---|
| Genes | 32 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 20 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence module contains several immune signaling genes with ILC1 enrichment. Hub genes include TMC8 (EVER2, involved in immune evasion of HPV), JAK1 (Janus kinase 1, cytokine signaling), IFNAR2 (interferon-alpha/beta receptor subunit 2), CSK (C-terminal Src kinase, negative regulator of Src-family kinases in lymphocytes), RBL2 (retinoblastoma-like 2, cell cycle), PTGDR (prostaglandin D2 receptor), EIF4EBP2 (translational repressor), ARHGAP9 (Rho GTPase activating protein in hematopoietic cells), LCP2 (SLP-76, core lymphocyte signaling adaptor, core membership), HCLS1 (HS1, actin regulatory in lymphocytes), DENND2D (DENN domain, Rab GEF). JAK1 and IFNAR2 together strongly suggest interferon signaling. LCP2 (SLP-76) and CSK are canonical lymphocyte signaling molecules. The combination of JAK1, IFNAR2, and downstream signaling components points to a cytokine/interferon receptor signaling module in ILC1/NK cells.
Genes
AASDHPPT, ARHGAP9, CHURC1, CIDEB, CSK, DCAF7, DENND2D, EDEM2, EIF4EBP2, ESYT1, FGD3, HCLS1, HDLBP, HM13, HPS3, IFNAR2, JAK1, KPNB1, LCP2, MRFAP1L1, NDUFV1, NRDC, PIK3CD, PRKCH, PTGDR, RASAL3, RBBP4, RBL2, SLC25A40, TMC8, TSC22D4, URM1
Most correlated modules
- ILC1 Lymphocyte Signaling · correlation 0.93
- RNA Processing Mixed · correlation 0.89
- ILC Transcription Factor Program · correlation 0.89
- Actin Cytoskeleton Dynamics · correlation 0.88
- Cellular Metabolic Maintenance · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.