Cytoskeletal Remodeling
Gene co-expression module in Innate lymphoid cells
| Category | Cytoskeleton & motility |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 17 genes have a known function matching the annotation |
Why this annotation
SRGAP3 (Rho GAP regulating actin dynamics), MACF1 (actin-microtubule crosslinker essential for cell migration), IQGAP2 (scaffold linking Rac1/Cdc42 to actin), UTRN (utrophin, actin-binding cytoskeletal protein), PREX1 (Rac GEF activated by PI3K), and RDX-related signaling collectively define a cytoskeletal remodeling program. LTC4S (leukotriene C4 synthase) is notable as an NK/ILC effector molecule. KDM5A and KDM2A (histone demethylases) and BPTF (NURF chromatin remodeler) may co-regulate cytoskeletal gene expression. Strong coherence supports a genuine biological program. Significant delta_inflammation (0.536) is consistent with cytoskeletal remodeling during NK cell activation/migration in inflamed gut.
Genes
BCLAF1, BPTF, CBL, CDK13, IQGAP2, KDM2A, KDM5A, LTC4S, MACF1, NSD3, NUCB2, PREX1, SPINK2, SRGAP3, TTC3, UBTF, UTRN
Most correlated modules
- Golgi RNA Processing · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.