Golgi RNA Processing
Gene co-expression module in Innate lymphoid cells
| Category | RNA processing & translation |
|---|---|
| Genes | 20 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include GOLGA4, TGOLN2, GCC2 (Golgi trafficking), MLEC (lectin chaperone/glycoprotein folding in ER/Golgi), SPCS3 (signal peptidase complex), alongside RNA processing genes RBM25, DDX17, SCAF11, LUC7L3, PNN. The module reflects a mixed Golgi/ER trafficking and RNA splicing housekeeping program. ATM and SET add DNA damage/chromatin components. Moderate coherence with mostly weak memberships supports a mixed but related cellular maintenance program. Significant delta_inflammation (0.686) may reflect increased biosynthetic demand during inflammation.
Genes
ANKRD12, ATM, DDX17, GCC2, GOLGA4, LUC7L3, MIER1, MLEC, MYCBP2, PNN, PPP2R2A, RBM25, ROCK1, SCAF11, SET, SPCS3, SYNRG, TBL1XR1, TGOLN2, USP16
Most correlated modules
- Splicing & Transcription · correlation 0.96
- Endosomal Trafficking · correlation 0.94
- Pre-mRNA Splicing · correlation 0.92
- Innate Immune Activation · correlation 0.90
- RNA Chromatin Regulation · correlation 0.88
- Centrosome & Scaffolding · correlation 0.88
- RNA-binding & Splicing · correlation 0.87
- Cytoskeletal Remodeling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.