SPINK2 — Serine peptidase inhibitor Kazal type 2
SPINK2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SPINK2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mixed Metabolic Ambient Technical artifact | DPYD, ENO2, FABP6, FCGRT, GRAP, SMURF2, SYNJ2BP, TNFRSF10B +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Quiescent HSC State Stemness | ARHGEF17, BAALC, BIN1, CD52, GNAI1, HOPX, MZB1, RBPMS | |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, CDK13, IQGAP2, KDM2A, KDM5A, LTC4S +8 more | View in SCUBA |
About the gene
| Synonyms | HUSI-II |
|---|---|
| Chromosome | 4: 56809860-56821742 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Protease inhibitor, Serine protease inhibitor |
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.