LTC4S — Leukotriene C4 synthase
LTC4S belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LTC4S's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, CLIC3, ELN, FBLN2, FGF18 +5 more | View in SCUBA |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BCLAF1, BPTF, CBL, CDK13, IQGAP2, KDM2A, KDM5A, MACF1 +8 more | View in SCUBA |
| Lymphatic endothelial | Leukotriene Biosynthesis Lipid metabolism | ADIRF, AKAP12, APOLD1, EMP1, ITM2A, PLAC9, SNCG, THBD | View in SCUBA |
| Pericytes | Arterial Pericyte Identity Developmental | ATP13A3, BMX, FBLN2, GJA5, KCTD12, PLLP, SEMA3G, TMEM100 +1 more | View in SCUBA |
About the gene
| Synonyms | MGC33147 |
|---|---|
| Chromosome | 5: 179793980-179796647 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Lyase, Transferase |
| Biological process | Leukotriene biosynthesis, Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.