BCLAF1 — BCL2 associated transcription factor 1
BCLAF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BCLAF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Heat Shock Response Stress | CCNL1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5, MIDN +5 more | View in SCUBA |
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | CENPC, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X, EPC1 +11 more | |
| Innate lymphoid cells | Cytoskeletal Remodeling Cytoskeleton & motility | BPTF, CBL, CDK13, IQGAP2, KDM2A, KDM5A, LTC4S, MACF1 +8 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | CSNK1A1, DDX3X, DDX5, EWSR1, FUS, HNRNPH1, HNRNPH3, HNRNPU +11 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB RNA Regulation RNA processing & translation | ARIH2, ATP1A1, BNIP2, CALR, COG3, DDX6, EIF4G2, EIF4H +14 more | |
| Natural Killer cells | Glucocorticoid Response Immune regulation | AREG, ARF6, BEX2, BEX4, ELF1, ELL2, EPC1, GABARAPL1 +11 more | View in SCUBA |
About the gene
| Synonyms | BTF, KIAA0164 |
|---|---|
| Chromosome | 6: 136256627-136289851 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.