Proteostasis Stress Response
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes TRMT112 (tRNA and rRNA methyltransferase, ribosome biogenesis), NPM1 (nucleophosmin, ribosome biogenesis and stress response), POLR1D (RNA polymerase I subunit, rRNA transcription), ERP29 (ER luminal protein), ST13 (Hsp70/Hsc70 co-chaperone), SOD1 (superoxide dismutase, oxidative stress), GABARAPL2 (autophagy receptor), UQCRH/HIGD2A (mitochondrial Complex III components), BUB3 (spindle assembly checkpoint). The module is moderate coherence with many weak memberships, reflecting a mixed program. The combination of ribosome biogenesis (TRMT112, NPM1, POLR1D), chaperone/stress (ST13, SOD1), and autophagy (GABARAPL2) suggests a general cellular stress and proteostasis response. Neighbor context (M76 mitochondrial, M77 SUMOylation) supports a stress/quality control theme.
Genes
BUB3, ERP29, GABARAPL2, HIGD2A, NCOR1, NPM1, POLR1D, SOD1, ST13, TRMT112, UQCRH
Most correlated modules
- SUMOylation Program · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.