ST13 — ST13 Hsp70 interacting protein
ST13 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ST13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DDX46, DNAJC7, HSPA4, LSM14A, LUC7L3 +8 more | View in SCUBA |
| Gamma-delta T cells | ER/Osmotic Stress Stress | ABHD3, DNAJA4, FKBP4, HIBCH, HSD17B7, HSPA4, HSPB1, MBNL2 +7 more | |
| Goblet cells | mRNA Translation Initiation RNA processing & translation | EEF1A1, EEF1B2, EIF3D, EIF3E, EIF3F, EIF3L, PABPC1, RACK1 +2 more | View in SCUBA |
| Innate lymphoid cells | Proteostasis Stress Response Stress | BUB3, ERP29, GABARAPL2, HIGD2A, NCOR1, NPM1, POLR1D, SOD1 +2 more | View in SCUBA |
| Macrophages | Translation Initiation Housekeeping | AKR1B1, CAMLG, CAPZB, EEF1D, EEF2, EID1, EIF3D, EIF3E +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | ER Protein Glycosylation Protein processing & ER | ANAPC5, HNRNPM, LMAN2, PDAP1, PKM, PRKCSH, RHOA, RPN1 +3 more | |
| Smooth muscle cells | Translocon & Proteostasis Housekeeping | ATP6V0E1, CLTA, EIF3F, NOP10, NPC2, PSMA1, SEC61G, SUB1 +2 more | View in SCUBA |
About the gene
| Synonyms | FAM10A1, HIP, HSPABP1, P48, SNC6 |
|---|---|
| Chromosome | 22: 40824535-40856639 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.