SCUBA

NPM1 — Nucleophosmin 1

NPM1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NPM1's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsRibosome biogenesis
Housekeeping		APEX1, APRT, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA +17 moreView in SCUBA
CD8⁺ T cellsRibosome Biogenesis
RNA processing & translation		BTF3, CCND3, EIF3H, EIF3L, ERP29, FBL, FXYD5, LDHB +8 moreView in SCUBA
EndothelialTranslation Elongation
RNA processing & translation		CCNI, COMMD6, EEF1A1, EEF1B2, EEF2, EIF3F, EIF3L, EIF4B +7 moreView in SCUBA
EnterocytesNucleolar RNA-binding
RNA processing & translation		HMGB1, HMGN2, HNRNPA1, HNRNPA2B1, HNRNPA3, HSP90AA1, HSP90AB1, NCL +2 moreView in SCUBA
Gamma-delta T cellsAnabolic Activation Response
Housekeeping		ABHD5, ATF4, ATP6V0C, ATP6V1G1, BCL7B, BUD31, CALM2, CHRAC1 +26 more
Glial cellsRNA Translation Processing
RNA processing & translation		CYCS, EEF1B2, EEF1D, HNRNPA1, HNRNPH3, LDHA, NAP1L1, PFDN5 +5 moreView in SCUBA
Innate lymphoid cellsProteostasis Stress Response
Stress		BUB3, ERP29, GABARAPL2, HIGD2A, NCOR1, POLR1D, SOD1, ST13 +2 moreView in SCUBA
Lymphatic endothelialmRNA Translation Regulation
RNA processing & translation		BTF3, BZW1, CLIC1, EEF1B2, GAPDH, SDCBP, YBX1, YWHAEView in SCUBA
MacrophagesMitochondrial Biogenesis
Mitochondrial & OxPhos		AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 moreView in SCUBA
MonocytesBiosynthetic Metabolic Activation
Housekeeping		AHCY, EEF1B2, IMPDH2, NME1, NUCKS1, PABPC4, PEBP1, PRDX4 +4 moreView in SCUBA
Mucosal-associated invariant T cellTranslation Elongation
RNA processing & translation		BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, FTL +8 more
Natural Killer cellsOxidative Stress Response
Stress		BANF1, CCDC167, CCT6A, CHCHD2, HINT1, HMGN1, HNRNPF, PA2G4 +2 moreView in SCUBA
NeutrophilsTranslational Housekeeping
Housekeeping		COX4I1, EEF1A1, EEF1B2, GSTP1, MGST1, RACK1, UBA52, YBX1

About the gene

SynonymsB23, NPM
Chromosome5: 171387116-171411810
Predicted locationIntracellular
Essential geneYes
Protein classCancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins
Molecular functionChaperone, RNA-binding
Biological processHost-virus interaction

Function

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade. In complex with MYC enhances the transcription of MYC target genes. May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.