NCOR1 — Nuclear receptor corepressor 1
NCOR1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCOR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA & Chromatin Regulation RNA processing | ATRX, DCP2, DIP2A, HNRNPLL, KDM5B, OGDH, RIOK3, SAMD9 +7 more | View in SCUBA |
| Gamma-delta T cells | Rho GTPase Signaling Cytoskeletal | APOBR, ARHGEF3, ATP6V1H, BRCC3, CD46, CNDP2, CYB5R4, DCTN5 +14 more | |
| Innate lymphoid cells | Proteostasis Stress Response Stress | BUB3, ERP29, GABARAPL2, HIGD2A, NPM1, POLR1D, SOD1, ST13 +2 more | View in SCUBA |
| Macrophages | RNA Processing Housekeeping Housekeeping | BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more | View in SCUBA |
| Mucosal-associated invariant T cell | Integrin Actin Adhesion migration & adhesion | ACTR2, ANKRD10, ATP2B1, DDX46, HP1BP3, HPS3, JAK1, LINS1 +11 more |
About the gene
| Synonyms | hCIT529I10, hN-CoR, KIAA1047, MGC104216, N-CoR, PPP1R109, TRAC1 |
|---|---|
| Chromosome | 17: 16029065-16218185 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding, Repressor |
| Biological process | Biological rhythms, Transcription, Transcription regulation |
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.