TRMT112 — TRNA methyltransferase activator subunit 11-2
TRMT112 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRMT112's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Cullin-RING Ubiquitin Ligase Housekeeping | ARPC3, LAMTOR5, MRPL51, NDUFA11, NDUFB11, NDUFC2, OST4, RBX1 +3 more | View in SCUBA |
| Goblet cells | Proteostasis Housekeeping Housekeeping | ADRM1, EIF2S2, GNB2, MAGOHB, NME1, NUDC, OAZ1, PARK7 +4 more | View in SCUBA |
| Innate lymphoid cells | Proteostasis Stress Response Stress | BUB3, ERP29, GABARAPL2, HIGD2A, NCOR1, NPM1, POLR1D, SOD1 +2 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial OxPhos Complex Mitochondrial & OxPhos | COX6A1, COX6B1, COX6C, COX7A2, COX8A, DAD1, NDUFA1, NDUFB4 +6 more | View in SCUBA |
| Macrophages | Protein Homeostasis Mixed Housekeeping | ABRACL, ADI1, AP2S1, ATP5F1B, BRK1, CFL1, CHCHD2, CLTA +33 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cellular Housekeeping Housekeeping | ABI3, AP2M1, CD151, CD2, CKLF, DYNLL1, FDFT1, LRP10 +7 more | |
| Smooth muscle cells | Mitochondrial Housekeeping Housekeeping | APP, COX7A2L, EIF5B, GABARAPL2, LAMTOR4, NDUFAB1, PGAM1, SPCS2 +2 more | View in SCUBA |
About the gene
| Synonyms | HSPC152, HSPC170, hTrm112, TRM112, TRMT11-2 |
|---|---|
| Chromosome | 11: 64316460-64317559 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | rRNA processing |
Function
Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA. The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S- adenosyl L-methionine as methyl donor. The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species. Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production. Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.