BUB3 — BUB3 mitotic checkpoint protein
BUB3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BUB3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Cell Cycle Proliferation Cell cycle | ALYREF, ANP32E, BCL2L12, BIRC5, CENPW, CEP55, CKS1B, DTYMK +4 more | View in SCUBA |
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, CALCOCO2, CASP4, COMMD7, CTSD, CXCR6 +7 more | View in SCUBA |
| CD8⁺ T cells | G1/S Entry Checkpoint Cell cycle | ARHGAP11B, ARL6IP1, CALM2, CDKN2C, CKS2, EMC9, MZT1, PTTG1 | View in SCUBA |
| Innate lymphoid cells | Proteostasis Stress Response Stress | ERP29, GABARAPL2, HIGD2A, NCOR1, NPM1, POLR1D, SOD1, ST13 +2 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, CCDC167, CENPW, CENPX, DCTPP1 +34 more | View in SCUBA |
| Smooth muscle cells | Proliferative Biosynthesis Housekeeping | ARF5, CBX5, DCTN3, DUT, HMGN2, IDH2, KRTCAP2, MIF +7 more | View in SCUBA |
About the gene
| Synonyms | BUB3L |
|---|---|
| Chromosome | 10: 123154402-123170467 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Chromosome partition, Meiosis, Mitosis |
Function
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.